Materials and their use in the preparation of bioc

专利名称：Materials and their use in the preparation of

biocompatible surfaces

发明人：Jeremy Colin Russell,Ewan James Campbell申请号：US08/682536申请日：19960729公开号：US05739237A公开日：19980414

摘要：New materials having improved biocompatibility have novel zwitterionic groupsat the surface. The zwitterion is characterized by having at least one monovalent

substituent at the atom carrying the cationic charge which is an aryl group. Preferably theatom carries at least two, and preferably three such aryl, usually phenyl, groups. Thecationic group is preferably a triphenylphosphonium. Treatment of surfaces to providependant zwitterionic groups of the specified type have reduced platelet activation, whilstthey do not appear to reduce platelet adhesion. The invention has utility in the field ofblood contacting device, especially devices for implantation, such as vascular grafts.

申请人：BIOCOMPATIBLES LIMITED

代理机构：Sughrue, Mion, Zinn, Macpeak & Seas, PLLC

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