PROSTACYCLINE DERIVATIVES WITH A CYTOPROTECTIVE AC

专利名称：PROSTACYCLINE DERIVATIVES WITH A

CYTOPROTECTIVE ACTION ON THE KIDNEY

发明人：ADLER, GUIDO,SCHULTE-HERMANN,

ROLF,LOGE, OLAF

申请号：EP85903809.3申请日：19850718公开号：EP0191792B1公开日：19920122

摘要：we describe, in addition to its preparation process, medicine for thecytoprotection of kidney, liver, pancreas, and is characterized in that it contains

derivatives of formula (i), prostacyclin, in which r1 is hydrogen or alkyl, with 1 to 10 carbonatoms, a group - ch2-ch2 - ch = ch -, trans -, or - c = c -.w a hydroxymethyl group orfunctionally transformable in the hydroxy group, in which the oh group is in a positionalpha or beta, x group ch2 or an oxygen atom, z is hydrogen or a cyano group, a group ofstraight and branched chain saturated alkyl\ène with 1 to 5 atom are carbon, a c = cbond, or a direct connection.r2 is a group with straight and branched chain alkyl with 1 to6 carbon atoms. a free hydroxy group and r3 is functionally transformable and where r1represents hydrogen, their physiologically acceptable salts with bases.

申请人：SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN,SCHERINGAKTIENGESELLSCHAFT BERLIN UND BERGKAMEN

地址：MUELLERSTRASSE 170/178 POSTFACH 65 03 11; W-1000 BERLIN65,MUELLERSTRASSE 170/178 POSTFACH 65 03 11; W-1000 BERLIN 65

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