Chemical Modification of Proteins

专利名称：Chemical Modification of Proteins发明人：Goncalo Bernardes,Justin Chalker,Benjamin

Guy Davis

申请号：US15070976申请日：20160315

公开号：US20160326212A1公开日：20161110

摘要：The invention relates to methods for selectively converting a cysteine residue ina peptide or protein to the dehydroalanine (Dha) residue. The method also works onselenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dharesidue which may be converted to any natural or unnatural amino acid residue desiredwithout the alteration of the remainder of the peptide or protein. The invention alsoallows ligation of a desired peptide at any point rather than at a point where thereshould be a naturally occurring cysteine, thereby allowing native chemical ligation to beused in the synthesis of peptides that do not contain cysteine. The methodology allowsfor the synthesis of very large peptides.

申请人：R.P. Scherer Technologies, LLC

地址：Las Vegas NV US

国籍：US

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