Method and apparatus for noninvasive measurement o

专利名称：Method and apparatus for noninvasive

measurement of blood glucose byphotoacoustics

发明人：Mau-Song Chou申请号：US09/190940申请日：19981112公开号：US06049728A公开日：20000411

摘要：A method and apparatus for noninvasively measuring blood glucose levelsprovides an indirect, reagentless, differential, photoacoustic technique which responds toabsorption in a thin surface layer. An excitation source provides electromagnetic energywhich is utilized to irradiate the tissue, such as skin. The output of the radiation of theexcitation source at the desired wavelength is coupled through a transmission device,such as a fiber optic bundle, which irradiates the electromagnetic energy onto the bodysurface. Upon irradiation, acoustic energy is generated by the absorption of theelectromagnetic energy in a relatively thin layer of the sample to be measured,characterized by a heat-diffusing length. The acoustic energy is detected by the probewhich includes a measuring cell, reference cell, window and differential microphone.Absorption of the light beam results in periodic heating of the tissue, at and near thetissue surface. The air in contact with the tissue surface in the measuring cell is in turnheated, and produces an acoustic emission in the measuring cell. This acoustic emission isdetected with the differential microphone, one end of which is positioned in the

measuring cell and the other end of which is positioned in the reference cell. A processor

determines the concentration of the substance based upon the detected acoustic signal.

申请人：TRW INC.

代理人：Michael S. Yatsko

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