5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZAB

专利名称：5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLEDERIVATIVE BOTH HAVING AMPKACTIVATION EFFECT

发明人：TAMURA, Yuusuke,WADA, Toshihiro申请号：EP17799492.8申请日：20170519公开号：EP3459949A1公开日：20190327

摘要：Provided is a compound which is useful as an AMPK activator. A compoundrepresented by formula: wherein R is hydrogen, or substituted or unsubstituted alkyl; R issubstituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted orunsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstitutedheteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstitutedcycloalkenyl, or substituted or unsubstituted heterocyclyl; T is -CR= or -N=; X is a singlebond, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl,substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, orsubstituted or unsubstituted heterocyclyl; Y is substituted or unsubstituted aryl,substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl,substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl;Z is RR(O=)S=N-, RR(O=)S=N-R-, RR(O=)S=N-C(=O)-, (R)N=S(=O)(R)-, (R)N=S(=O)(R)-R-,RR(R-N=)S=N-, or the like; n is an integer 1 or 2; R and R are each independentlysubstituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted

or unsubstituted heterocyclyl, or the like; R is substituted or unsubstituted alkylene; R iseach independently hydrogen, cyano, substituted or unsubstituted alkyl, substituted orunsubstituted alkylcarbonyl, or the like; R is hydrogen, cyano, substituted orunsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted orunsubstituted alkyloxycarbonyl or the like; and R, R and R are each independentlyhydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl,substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substitutedor unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted orunsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted orunsubstituted heterocyclyl, or the like, or its pharmaceutically acceptable salt.

申请人：Shionogi & Co., Ltd

地址：1-8, Doshomachi 3-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP

国籍：JP

代理机构：Vossius & Partner Patentanwälte Rechtsanwälte mbB

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