Aminopyrrole derivatives

专利名称：Aminopyrrole derivatives

发明人：Giorgio Tarzia,Gianbattista Panzone申请号：US05/960386申请日：19781113公开号：US04211709A公开日：19800708

摘要：Pharmacologically-active aminopyrrole derivatives of the formula ##STR1##wherein: R is selected from hydrogen, (C.sub.1-4)alkyl, benzyl and chlorobenzyl;

R.sub.1 is selected from hydrogen, (C. sub.1-4)alkyl, phenyl and phenyl substituted bya radical selected from methyl, ethyl, methoxy, ethoxy, benzyloxy, fluoro, chloro andbromo; < P>

R.sub.2 and R.sub.3 individually represent hydrogen or (C. sub.1-4)alkyl or, takentogether, represent an isopropylidene, a benzylidene or a chlorobenzylidene radical;

< P>R.sub.4 is selected from (C.sub.2-4)alkanoyl; carbo(C.sub.1-3)alkoxy; benzoyl,benzoyl substituted by a radical selected from chloro, methoxy or ethoxy; carbamoyl,methylcarbamoyl and phenyl carbamoyl;

< P>R.sub.5 is selected from hydrogen, (C.sub.1-4)alkyl, carbo(C.sub.1-3) alkoxy,carbomethoxymethyl, carbethoxymethyl, trifluoromethyl and carbamoyl, with theproviso that when R is hydrogen, R.sub.1 and R.sub.5 are methyl and R. sub.4 iscarbethoxy, and R.sub.2 and R.sub.3 cannot simultaneously represent hydrogen;

and a salt thereof with a pharmaceutically-acceptable acid.

The compounds have anti-inflammatory and CNS-depressant utility. They are alsouseful as analgesics and antipyretics and display a very low degree of anti- ulcerogenicactivity.

申请人：GRUPPO LEPETIT SPA

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