N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzene

专利名称：N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and theirtherapeutic use

发明人：Lisa Patel,Stephen Allan Smith,Iain Robert

Greig,Samuel Cameron Williams

申请号：US15786021申请日：20171017公开号：US10029979B2公开日：20180724

摘要：The present invention pertains generally to the field of therapeutic compounds.More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to hereinas HMC compounds) that are useful, for example, in the treatment of disorders (e.g.,diseases) including, inflammation and/or joint destruction and/or bone loss; disordersmediated by excessive and/or inappropriate and/or prolonged activation of the immunesystem; inflammatory and autoimmune disorders, for example, rheumatoid arthritis;psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (COPD); asthma;atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis;systemic lupus erythematosus; Sjogren's syndrome; a disorder associated with bone loss,such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis,

osteoporosis, cancer-associated bone disease, or Paget's disease; cancer, such as ahaematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solidtumor cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer,renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer,prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, ormelanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma;or a rare vasculitide, such as Behçet's disease. The present invention also pertains topharmaceutical compositions comprising such compounds, and the use of suchcompounds and compositions, for example, in therapy.

申请人：PIMCO 26 LIMITED

地址：London GB

国籍：GB

代理机构：Swanson & Bratschun, L.L.C.

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