专利名称：DECHALCOGENATIVE METHODS FOR THE
PREPARATION OF ALLYLIC SULFIDES
发明人：CRICH, David,KARATHOLUVHU,
Maheswaran,KRISHNAMURTHY,Venkataramanan,HUTTON, Thomas,K.,BREBION, Franck,SUBRAMANIAN,Venkataraman
申请号：EP08743377.7申请日：20080429公开号：EP2139859A1公开日：20100106
摘要：A dechalcogenative method for the preparation of an allylic sulfide comprisescontacting an activated chalcogenide of Formula (I) with a thiol of Formula (II) for aperiod of time sufficient to form an intermediate of Formula (III), and supplying sufficientactivation energy to the intermediate of Formula (III), in a suitable solvent, preferably inthe absence of a phosphine or other thiophile, to induce a [2,3]-sigmatropic
rearrangement therein to form an allylic sulfide of Formula (IV), with concomitant loss ofchalcogen Z, as set forth in the following reaction scheme, wherein X is an activatinggroup selected from the group consisting of CN, S-pyridyl, S-heteroaryl, SO2-aryl, andSO3Y; Y is an alkali metal ion; Z is Se or S; R1, R2, R3, R4, and R5 are each independently Hor a hydrocarbon moiety; and R is an organic moiety.
申请人：The Board Of Trustees Of The University Of Illinois
地址：352 Henry Administration Building 506 South Wright Street Urbana, IL 68101 US
国籍：US
代理机构：Schnappauf, Georg
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