9, 10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL

专利名称：9, 10-SECOPREGNANE DERIVATIVE AND

PHARMACEUTICAL

发明人：Fujieda, Hiroki,Yasufuku, Shoji,Shirai,

Masaaki,Otsu, Hironori

申请号：AU2013201280申请日：20130305公开号：AU2013201280A1公开日：20130321

摘要：#$%^&*AU2013201280A120130321.pdf##### ABSTRACT A main object of theinvention is to provide a novel useful vitamin D3 derivative, which has an excellent vitaminD3 activity and, as compared with conventional vitamin D3 derivatives, has a relativelysmall amount of influence on the systemic calcium metabolism. The invention includes a9,10-secopregnane derivative of the following general formula [1] and a pharmaceuticalcomposition containing it as active ingredient. [Formula 1] R 3 200 CH3 Y R1 16 0 R 2 Z aRb HO _ OH Rc Rd In the general formula [1], the following partial structure between the16-position and the 17-position means a single bond or a double bond: [Formula 2] 117 Yis a single bond, an alkylene, an alkenylene or phenylene; R' and R2 are the same ordifferent, each represents hydrogen, an alkyl or a cycloalkyl; or R1 and R2 taken togetherwith the adjacent carbon atom, form a cycloalkyl; R3 is hydrogen or methyl; Z ishydrogen, 1112 hydroxy or -NR R 118

申请人：Nippon Shinyaku Co., Ltd.

代理人：Callinans

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