POLYMERIZATION WITH PRECIPITATION OF PROTEINS FOR

专利名称：POLYMERIZATION WITH PRECIPITATION

OF PROTEINS FOR ELUTION INPHYSIOLOGICAL SOLUTION

发明人：SAWHNEY, AMARPREET, S.申请号：EP08725234申请日：20080206公开号：EP2121057A4公开日：20121010

摘要：Methods and compositions for polymerizing materials with the process ofmaking the material causing precipitation of an agent that is subsequently released bythe material. In some aspects, controlled delivery of bioactive substances from

biodegradable hydro gels is disclosed. In certain embodiments, biodegradable hydrogelsformed in situ comprise entrapped precipitated proteins that are ordinarily watersoluble. The dissolving and release of the bioactive substance is impeded by thehydrogel structure and takes place at a slow rate, thus controlling the release of saidbioactive substance from the hydrogel. Thus a bioactive substance that would normallybe rapidly dissolved in a physiological surrounding is, instead, released in a controlledmanner. The hydrogel phase also serves to protect the bioactive agent from cells andenzymes present in physiological surroundings.

申请人：INCEPT LLC

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