专利名称：BICYCLIC TRIAZOLE AND PYRAZOLE
LACTAMS AS ALLOSTERIC MODULATORS OFMGLUR5 RECEPTORS
发明人：CONN, P., JEFFREY,LINDSLEY, CRAIG,
W.,STAUFFER, SHAUN, R.,BARTOLOME-NEBREDA, JOSE, MANUEL,CONDE-CEIDE,SUSANA,MACDONALD, GREGOR,JAMES,TONG, HAN, MIN,JONES, CARRIE,K.,ALCAZAR-VACA, MANUEL, JESUS,ANDRES-GIL, JOSE, IGNACIO,MALOSH, CHRYSA
申请号：EP11848685申请日：20111216公开号：EP2651222A4公开日：20140430
摘要：In one aspect, the invention relates to bicyclic triazole and pyrazole lactams,derivatives thereof, and related compounds, which are useful as positive allostericmodulators of the metabotropic glutamate receptor subtype 5 (mGluR5); syntheticmethods for making the compounds; pharmaceutical compositions comprising thecompounds; and methods of treating neurological and psychiatric disorders associatedwith glutamate dysfunction using the compounds and compositions. This abstract isintended as a scanning tool for purposes of searching in the particular art and is notintended to be limiting of the present invention.
申请人：VANDERBILT UNIVERSITY
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