SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES

专利名称：SURFACE CHEMISTRY AND DEPOSITION

TECHNIQUES

发明人：SCHWARTZ, JERROD,QUAKE, STEPHEN,

R.,MRKSICH, MILAN

申请号：EP08728823申请日：20080201公开号：EP2108042A4公开日：20100414

摘要：Surface chemistries for the visualization of labeled single molecules (analytes)with improved signal-to-noise properties are provided. To be observed, analytemolecules are bound to surface attachment features that are spaced apart on thesurface such that when the analytes are labeled adjacent analytes are opticallyresolvable from each other. One way to express this concept is that binding elementsshould be spaced apart such that the Guassian point spread functions of adjacent labelsdo not overlap. Another way of expressing this concept is that the surface bindingelements should be spaced apart by a distance equal to at least the diffraction limit foran optical label attached to the bound analytes.

申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY,STANFORDUNIVERSITY,UNIVERSITY OF CHICAGO

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